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In the event the response to an opioid antagonist is suboptimal or only transient in mother nature, administer supplemental antagonist as directed with the product or service’s prescribing data. The respiratory depressant effects of promethazine are certainly not reversed by opioid antagonists, such as naloxone.

Though serious, everyday living-threatening, or deadly respiratory despair can come about at any time in the course of the use of promethazine HCl and codeine phosphate oral Alternative, the risk is best during the initiation of therapy, when promethazine HCl and codeine phosphate oral Remedy is applied concomitantly with other medication that may induce respiratory depression [see Warnings and Safety measures (five.

The approximated qualifications chance of big birth defects and miscarriage with the indicated inhabitants is unfamiliar. All pregnancies Possess a qualifications threat of start defect, reduction, or other adverse results.

Asthma along with other Pulmonary Illness The use of promethazine HCl and codeine phosphate oral solution in people with acute or serious bronchial asthma within an unmonitored setting or from the absence of resuscitative devices is contraindicated [see Contraindications (4)]. Opioid analgesics and antitussives, such as codeine, among the list of Energetic elements in promethazine HCl and codeine phosphate oral Remedy, should not be used in individuals with acute febrile health issues linked to effective cough or in clients with Serious respiratory disease in which interference with capacity to clear the tracheobronchial tree of secretions might have a deleterious impact on the client’s respiratory functionality.

The codeine in promethazine HCl and codeine phosphate oral Option may perhaps lead to constipation or obstructive bowel sickness, especially in clients with fundamental intestinal motility Diseases. Use with caution in clients with fundamental intestinal motility Conditions.

Mainly because these reactions could be documented voluntarily from the inhabitants of uncertain size, It's not constantly doable to reliably estimate their frequency or build a causal marriage to drug exposure.

Use warning When thinking about using promethazine HCl and codeine phosphate oral Option in clients sixty five years of age or more mature.

This may be linked to a lower in efficacy, and in some people, may well lead to indicators and indicators of opioid withdrawal.

Use warning when considering the use of promethazine HCl and codeine phosphate oral Resolution in sufferers 65 a long time of age or older.

Lifetime-threatening respiratory despair and Loss of life have transpired in small children who obtained codeine. The majority of the noted scenarios transpired adhering to tonsillectomy and/or adenoidectomy, and plenty of of the youngsters had proof of currently being an ultra-swift metabolizer of codeine resulting from get more info a CYP2D6 polymorphism [see Warnings and Safety measures (five.three)]. Promethazine HCl and codeine phosphate oral solution is contraindicated in children more youthful than twelve a long time of age As well as in youngsters youthful than eighteen many years of age next tonsillectomy and/or adenoidectomy [see Contraindications (4)].

Postmarketing scenarios of respiratory depression, together with fatalities are noted with utilization of promethazine in pediatric patients.

There aren't any offered info with promethazine HCl and codeine phosphate oral Remedy use in Expecting Females to tell a drug-related danger for adverse developmental results.

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Postmarketing conditions of respiratory despair, together with fatalities are actually described with usage of promethazine in pediatric sufferers.